Tuesday, June 28, 2011

Q: What advantage vasopressin has over other pressors particularly over epinephrine in code (ACLS) situation?

Answer: Most pressors including epinephrine loses much of its effectiveness in an acidotic plasma, but vasopressin demonstrates vasoconstricting efficacy even with severe acidosis. 

Wenzel V, Krismer AC, Arntz HR, Sitter H, Stadlbauer KH, Lindner KH. A comparison of vasopressin and epinephrine for out-of-hospital cardiopulmonary resuscitation. N Engl J Med. Jan 8 2004;350(2):105-13