Q: How Desmopressin (DDAVP) helps in uremic bleeding (Mechanism of action)?


Answer: The mechanism of action of DDAVP is believed to be - by releasing factor VIII from storage sites, potentially increasing the concentration of factor VIII and minimizing the effects of dysfunctional vWF. Larger vWF–factor-VIII multimers are reported in the plasma after infusion of DDAVP, which probably reduce bleeding time.