Thursday, June 2, 2011

Q: Uremia prolongs

C) PT and PTT
D) Bleeding Time
E) PT, PTT and Bleedind Time

Answer: D) Bleeding time

Uremia is unique in the sense that it doesn't effect PT or PTT. DDAVP is the first line treatment, which acts promptly but has a short duration of action of few hours and exhibits tachyphylaxis. Conjugated estrogens has also shown promise but are slower in the onset of action (about 6 hours) but effect lasts for about 2 weeks.