Wednesday, June 8, 2011

B. anthracis and iron

B. anthracis must acquire iron in order to grow and proliferate in its host environment. The most readily available iron sources for pathogenic bacteria are the heme. In order to scavenge heme from hemoglobin and myoglobin, B. anthracis uses its secretory siderophore. These proteins separate heme from hemoglobin, allowing surface proteins of B. anthracis to transport it into the cell.

1. Hotta K, Kim CY, Fox DT, Koppisch AT. - Siderophore-mediated iron acquisition in Bacillus anthracis and related strains.- Microbiology. 2010 Jul;156(Pt 7):1918-25. Epub 2010 May 13.

2. Purohit M, Sassi-Gaha S, Rest RF., Rapid sporulation of Bacillus anthracis in a high iron, glucose-free medium. J Microbiol Methods. 2010 Sep;82(3):282-7. Epub 2010 Jul 16.

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